#LegoChemistry-Inspired Synthesis of Extra-large Pore# Zeolite ECNU-9 with Intersecting 14*12-Ring Channels

#LegoChemistry-Inspired Synthesis of Extra-large Pore# Zeolite ECNU-9 with Intersecting 14*12-Ring Channels

Solution and Solid State #StructuralChemistry of Th(IV) and U(IV) 4-#Hydroxybenzoates

Solution and Solid State #StructuralChemistry of Th(IV) and U(IV) 4-#Hydroxybenzoates

The #MedicinalChemistry and Use of #Myosin II #Inhibitor ( S)-#Blebbistatin and Its Derivatives

The #MedicinalChemistry and Use of #Myosin II #Inhibitor ( S)-#Blebbistatin and Its Derivatives

Growth, carcass traits, cecal microbial counts, and #bloodchemistry of #meat-type quail fed #diets supplemented with #humicacid and #blackcuminseeds

Growth, carcass traits, cecal microbial counts, and #bloodchemistry of #meat-type quail fed #diets supplemented with #humicacid and #blackcuminseeds

#NovelPeptide Ion #Chemistry Associated with Gold (I) #Cationization: Preferential Cleavage at #Lysine Residues

#NovelPeptide Ion #Chemistry Associated with Gold (I) #Cationization: Preferential Cleavage at #Lysine Residues

From underlying #chemistry to #therapeutic potential: open questions in the new field of #lysine #polyphosphorylation

From underlying #chemistry to #therapeutic potential: open questions in the new field of #lysine #polyphosphorylation

#CarbonChemistry in IRC+10216: #Infrared Detection of #Diacetylene

#CarbonChemistry in IRC+10216: #Infrared Detection of #Diacetylene

Deactivation of excited states in transition #metalcomplexes: Insight from #computationalchemistry

Deactivation of excited states in transition #metalcomplexes: Insight from #computationalchemistry

Evaluation of BD Vacutainer® Barricor™ #blood collection tubes for routine #chemistry testing on a #RocheCobas® 8000 Platform

Evaluation of BD Vacutainer® Barricor™ #blood collection tubes for routine #chemistry testing on a #RocheCobas® 8000 Platform

Application of #bioconjugation #chemistry on #biosensor fabrication for detection of #TAR-DNA binding #protein 43

Application of #bioconjugation #chemistry on #biosensor fabrication for detection of #TAR-DNA binding #protein 43

Application of #bioconjugation #chemistry on #biosensor fabrication for detection of #TAR-DNA binding #protein 43

Application of #bioconjugation #chemistry on #biosensor fabrication for detection of #TAR-DNA binding #protein 43

A matrix-assisted laser desorption/ionization mass spectroscopy method for the analysis of small molecules by integrating chemical labeling with the supramolecular chemistry of cucurbituril

Abstract

Although several methods have realized the analysis of low molecular weight (LMW) compounds using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) by overcoming the problem of interference with MS signals in the low mass region derived from conventional organic matrices, this emerging field still requires strategies to address the issue of analyzing complex samples containing LMW components in addition to the LMW compounds of interest, and solve the problem of lack of universality. 

The recent progress of isoxazole in medicinal chemistry

Abstract

Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Developing compounds with heterocycle rings has been one of the trends. The integration of isoxazole ring can offer improved physical-chemical properties. Because of the unique profiles, isoxazole ring becomes a popular moiety in compounds design

A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models

Abstract

Photodynamic therapy (PDT) represents a non-toxic and non-mutagenic antitumor therapy. The photosensitizer's (PS) chemo-physical properties are essential for the therapy, being responsible for the biological effects induced in the targeted tissues. In this study, we present the synthesis and development of some glycoconjugated porphyrins based on lectin-type receptor interaction. They were tested in vitro for finally choosing the most effective chemical structure for an optimum antitumor outcome.

Defect Chemistry of Oxides for Energy Applications

Abstract

Oxides are widely used for energy applications, as solid electrolytes in various solid oxide fuel cell devices or as catalysts (often associated with noble metal particles) for numerous reactions involving oxidation or reduction. Defects are the major factors governing the efficiency of a given oxide for the above applications. In this paper, the common defects in oxide systems and external factors influencing the defect concentration and distribution are presented, with special emphasis on ceria (CeO2 ) based materials.

Click Chemistry-based Discovery of [3-Hydroxy-5-(1H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia.

Abstract

As a gene associated with anemia, the #erythropoiesis gene is physiologically expressed under hypoxia regulated by hypoxia-inducing factor-α (HIF-α). Thus, stabilizing HIF-α is a potent strategy to stimulate the expression and secretion of erythropoiesis. In this study we applied click #chemistry to the discovery of HIF prolyl hydroxylase 2 (HIF-PHD2) inhibitors for the first time and a series of triazole compounds showed preferable inhibitory activity in #fluorescence #polarization assay.

Exploiting Synergistic Effects in Organozinc Chemistry for Direct Stereoselective C-Glycosylation Reactions at Room Temperature

Abstract

Pairing a range of bis(aryl) zinc reagents ZnAr2 with the stronger Lewis acidic [(ZnArF2)] (ArF = C6F5), enables highly stereoselective cross-coupling between glycosyl bromides and ZnAr2 without the use of a transition metal. Reactions occur at room temperature with excellent levels of stereoselectivity, where ZnArF2 acts as a non-coupling partner although its presence is crucial for the execution of the C(sp2)-C(sp3) bond formation process.

Biological chemistry without borders

Recent Developments in Carbonylation Chemistry Using [13 C]CO, [11 C]CO and [14 C]CO

Abstract

Carbon monoxide represents the most important C1-building block for the chemical industry, both for the production of bulk and fine chemicals, but also for synthetic fuels. Yet, its toxicity and subsequently its cautious handling has limited its applications in medicinal chemistry research and in particular for the synthesis of pharmaceutically relevant molecules. Recent years have nevertheless witnessed a considerable headway on the development of carbon monoxide surrogates and reactor systems

A Recent History of HNO (Nitroxyl) Chemistry, Pharmacology and Therapeutic Potential.

Abstract

Due to the excitement surrounding the discovery of nitric oxide (NO) as an endogenously generated signaling molecule, numerous other nitrogen oxides were also investigated as possible physiological mediators. Among these was nitroxyl (HNO). Over the past 25 years or so, a significant amount of work by this lab and many others has discovered that 

Theoretical Exploration of the Role of CO2 in an Imidazolium Cation-Based Ionic Liquid | SciTechnol

Theoretical Exploration of the Role of CO2 in an Imidazolium Cation-Based Ionic Liquid | SciTechnol: Optimized structures of imidazolium cation-based ionic liquids (ILs) and CO2 were obtained using the Gaussian 09 software package and density functional theory (B3LYP/6-3..

The Simms Constants as Parameters in Hyperbolic Functions Related to Acid-Base Titration Curves | SciTechnol

The Simms Constants as Parameters in Hyperbolic Functions Related to Acid-Base Titration Curves | SciTechnol: The Simms constants (gi) are parameters of transformed equations for acid-base titration curves, obtained from rational functions of the Padé type. The relationshi..

Impact of crop residue management on crop production and soil chemistry after seven years of crop rotation in temperate climate, loamy soils.

Abstract

Society is increasingly demanding a more sustainable management of agro-ecosystems in a context of climate change and an ever growing global population. The fate of crop residues is one of the important management aspects under debate, since it represents an unneglectable quantity of organic matter which can be kept in or removed from the agro-ecosystem. The topic of residue management is not new, but the need for global conclusion on the impact of crop residue management on the agro-ecosystem linked to local pedo-climatic conditions has become apparent with an increasing amount of studies showing a diversity of conclusions. 

Radical Rearrangement #Chemistry in #Ultraviolet #Photodissociation of #Iodotyrosine Systems: Insights from Metastable Dissociation,#Infrared Ion# Spectroscopy, and Reaction Pathway Calculations

Abstract

We report on the ultraviolet photodissociation (UVPD) chemistry of protonated tyrosine, iodotyrosine, and diiodotyrosine. Distonic loss of the iodine creates a high-energy radical at the aromatic ring that engages in hydrogen/proton rearrangement chemistry. Based on UVPD kinetics measurements, the appearance of this radical is coincident with the UV irradiation pulse (8 ns). Conversely, sequential UVPD product ions exhibit metastable decay on ca. 100 ns timescales.

Elucidating the role of surface chemistry on cationic phosphorus dendrimer-siRNA complexation

Abstract

In the field of dendrimers targeting small interfering RNA (siRNA) delivery, dendrimer structural properties, such as the flexibility/rigidity ratio, play a crucial role in the efficiency of complexation. However, advances in organic chemistry have enabled the development of dendrimers that differ only by a single atom on their surface terminals. This is the case for cationic phosphorus dendrimers functionalized with either pyrrolidinium (DP) or morpholinium (DM) terminal groups. 

Achieving biopolymer synergy in systems chemistry

Abstract

Synthetic and materials chemistry initiatives have enabled the translation of the macromolecular functions of biology into synthetic frameworks. These explorations into alternative chemistries of life attempt to capture the versatile functionality and adaptability of biopolymers in new orthogonal scaffolds. Information storage and transfer, however, so beautifully represented in the central dogma of biology, require multiple components functioning synergistically. Over a single decade, the emerging field of systems chemistry has begun to catalyze the construction of mutualistic biopolymer networks, and t

Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in rats.

Abstract

PEGylated polylysine dendrimers have demonstrated potential as inhalable drug delivery systems that can improve the treatment of lung cancers. Their treatment potential may be enhanced by developing constructs that display prolonged lung retention, together with good systemic absorption, the capacity to passively target lung tumours from the blood and highly selective, yet rapid liberation in the tumour microenvironment. This study sought to characterise how the nature of cathepsin B cleavable peptide linkers, used to conjugate doxorubicin to a PEGylated (PEG570) G4 polylysine dendrimer, affect drug liberation kinetics and intravenous and pulmonary pharmacokinetics in rats. The construct bearing a self-emolative diglycolic acid-V-Citrulline linker exhibited faster doxorubicin release kinetics compared to constructs bearing self emolative diglycolic acid-GLFG, or non-self emolative glutaric acid-GLFG linkers. The V-Citrulline construct exhibited slower plasma clearance, but faster absorption from the lungs than a GLFG construct, although mucociliary clearance and urinary elimination were unchanged. Doxorubicin-conjugation enhanced localisation in the bronchoalveolar lavage fluid compared to lung tissue, suggesting that projection of doxorubicin from the dendrimer surface reduced tissue uptake. These data show that the linker chemistry employed to conjugate drugs to PEGylated carriers can affect drug release profiles and systemic and lung disposition.

KEYWORDS:

cathepsin B; dendrimer; doxorubicin; lung clearance; pharmacokinetics; pulmonary

Quality Control Practices for Chemistry and Immunochemistry in a Cohort of 21 Large Academic Medical Centers.

Abstract

OBJECTIVES:

In the United States, minimum standards for quality control (QC) are specified in federal law under the Clinical Laboratory Improvement Amendment and its revisions. Beyond meeting this required standard, laboratories have flexibility to determine their overall QC program.

METHODS:

We surveyed chemistry and immunochemistry QC procedures at 21 clinical laboratories within leading academic medical centers to assess if standardized QC practices exist for chemistry and immunochemistry testing.

RESULTS:

We observed significant variation and unexpected similarities in practice across laboratories, including QC frequency, cutoffs, number of levels analyzed, and other features.

CONCLUSIONS:

This variation in practice indicates an opportunity exists to establish an evidence-based approach to QC that can be generalized across institutions.