Wide #spectral response #photothermal #catalysis-fenton coupling systems with 3D hierarchical Fe3O4/Ag/Bi2MoO6 ternary hetero-superstructural magnetic #microspheres for efficient high-toxic #organic #pollutants removal

Facile one-step synthesis of #onion-like #carbon modified #ultrathin g-C3N4 2D #nanosheets with enhanced visible-light #photocatalytic performance

#Synthesis and #evaluation of 4-cycloheptylphenols as selective #Estrogen receptor-#βagonists (SERBAs)

#Synthesis and #antifibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives

#Discovery of long-chain #salicylketoxime derivatives as #monoacylglycerollipase (MAGL) #inhibitors

#Noncytotoxic #nanomolar concentrations of #bisphenol A induce#human #mesenchymal #stemcell #adipogenesis and #osteogenesis

#Zincoxide #nanoparticles alter the #wheat physiological response and reduce the #cadmium uptake by #plants

#Bioaccumulation and #human #health risks of OCPs and #PCBs in #freshwater products of# Northeast #China

Dissolved #organic matter processing and #photoreactivity in a #wastewater treatment constructed #wetland

Increased #apolipoprotein M induced by lack of #scavenger receptor BI is not activated via HDL-mediated #cholesterol uptake in #hepatocytes

A novel MFSD8 mutation in a #Russian patient with #neuronal #ceroidlipofuscinosis type 7: a case report

#Evaluation of the impact of CYP1A2 induction by #charbroiled meal on #metabolic #phenotype

Highly #sensitive #ELISA for the# serological detection of #murinerotavirus EDIM based on its major #immunogen VP6

Saturday, 25 August 2018

Image-guided #chemistry altering #biology: An #invivo study of #thermoembolization

#Alkali-#Oxygen Batteries Based on #Reversible #Superoxide #Chemistry

#Hominin evolutionary #thanatology from the #mortuary to funerary realm: the #palaeoanthropological bridge between #chemistry and #culture

#Surfacechemistry and buried interfaces in all-#inorganic #nanocrystalline solids

A conformationally adaptive #macrocycle: conformational #complexity and host-guest #chemistry of zorb[4]arene

The #phenylvinylether-methanol complex: a model system for #quantumchemistry benchmarking

#Discovery of a Potent #α-Galactosidase #Inhibitor by #inSitu Analysis of a Library of #Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click #Chemistry

Rapid #Bioorthogonal #Chemistry Enables #inSitu Modulation of the #StemCell Behavior in 3D without External Triggers

#Biosynthetic #Baeyer-Villiger #Chemistry Enables Access to Two #Anthracene #Scaffolds from a Single #Gene #Cluster in Deep-Sea-Derived #Streptomycesolivaceus SCSIO T05

O-GlcNAcylation site mapping by (#azide-#alkyne) click #chemistry and #massspectrometry following intensive fractionation of #skeletalmuscle #cells #proteins

Fe-T1 Sensor Based on Coordination #Chemistry for Sensitive and Versatile #Bioanalysis

Need for Laboratory #Ecosystems to Unravel the #Structures and Functions of #Soil MicrobialCommunities Mediated by #Chemistry

#Rational application of #drug promiscuity in #medicinalchemistry

#Sigma metrics for assessing the #analytical quality of #clinicalchemistry #assays: a comparison of two approaches: #Electronic supplementary material available online for this article

#TannicAcid-Based Multifunctional #Hydrogels with Facile Adjustable #Adhesion and #Cohesion Contributed by #Polyphenol #SupramolecularChemistry

#Supramolecular Host-Guest #Chemistry-Based Folate/#Riboflavin Functionalization and #Cancer #Cell Labeling of #Nanoparticles

#Synthesis, Self-Assembly, and #DrugDelivery Characteristics of Poly(methyl caprolactone-co-caprolactone)-b-poly(ethylene oxide) #Copolymers with Variable Compositions of #Hydrophobic Blocks: Combining #Chemistry and #Microfluidic Processing for #Polymeric #Nanomedicines

#Synthesis, Self-Assembly, and #DrugDelivery Characteristics of Poly(methyl caprolactone-co-caprolactone)-b-poly(ethylene oxide) #Copolymers with Variable Compositions of #Hydrophobic Blocks: Combining #Chemistry and #Microfluidic Processing for #Polymeric #Nanomedicines

#Heterometallic Cu/Ln #cluster #chemistry: #ferromagnetically-coupled {Cu4Ln2} #complexes exhibiting single-molecule #magnetism and #magnetocaloric properties

#Catalytic #chemistry of #glucose oxidase in #cancer #diagnosis and #treatment

Mo6+ #Cation #Enrichment of the #Structure #Chemistry of #Iodates: #Syntheses, #Structures, and #Calculations of Ba(MoO2)2(IO3)4O, Ba3[(MoO2)2(IO3)4O(OH)4]•2H2O, and Sr[(MoO2)6(IO4)2O4]•H2O

Mo6+ #Cation #Enrichment of the #Structure #Chemistry of #Iodates: #Syntheses, #Structures, and #Calculations of Ba(MoO2)2(IO3)4O, Ba3[(MoO2)2(IO3)4O(OH)4]·2H2O, and Sr[(MoO2)6(IO4)2O4]·H2O

Wednesday, 22 August 2018

Intrinsically Tuning the #Electromechanical Properties of #ElastomericDielectrics: A #Chemistry Perspective

"Click" #Chemistry for #Medicine and #Biology

#Electrochemical #aptasensor using optimized #surfacechemistry for the detection of #Mycobacteriumtuberculosis secreted #protein #MPT64 in #human #serum

Comparisons of #metabolite profile from paired #serum and #ethylenediaminetetraaceticacid-#plasma samples using dry #chemistry #technology: An emergency department perspective

Reaction Selectivity in On-#SurfaceChemistry by Surface Coverage Control - #Alkyne#Dimerization versus #Alkyne #Trimerization

#Homogeneous and #Gas-Liquid #Catellani-type Reaction Enabled by Continuous-Flow #Chemistry

Soluble #Hetero-Polyoxovanadates and Their Solution #Chemistry Analyzed by #ElectrosprayIonization #MassSpectrometry

Influence of Surface Charges/#Chemistry on the #Catalysis of #Perovskite Complexes

New Coordination #Polymers of #Copper(I) and #Silver(I) with #Pyrazine and #Piperazine: A Step Toward #GreenChemistry and #Optoelectronic Applications

Recent trends in click #chemistry as a promising #technology for# virus-related #research

Influence of peat fires on the rainwater #chemistry in intra-mountain basins with specific atmospheric circulations (#EasternCarpathians, #Romania)

#Crystallographic study of dioxygen #chemistry in a #copper-containing #nitrite #reductase from #Geobacillus #thermodenitrificans

IMAGINE: #neutrons reveal #enzyme #chemistry

Monday, 20 August 2018

Charge Accumulation and Multi-Electron #Photoredox #Chemistry with a #Sensitizer-Catalyst-Sensitizer Triad

From #chemistry to #fruit flies: An unpredictable series of fortunate conversations

Post-functionalisation of #Tris-pyridylAluminate #Ligands: #Chirality, Coordination and#SupramolecularChemistry

Comparison of #soybean hull pre-treatments to obtain #cellulose and chemical derivatives: #Physicalchemistry characterization

Solvation #Chemistry of #LithiumNitrate in #Carbonate #Electrolyte for High-Voltage #Lithium#Metal Battery

#Perturbation Theory Machine Learning Models: Theory, Regulatory Issues, and Applications to #OrganicSynthesis, #MedicinalChemistry, #Protein #Research, and #Technology

Differential and Interactive Effects of Substrate #Topography and #Chemistry on Human #Mesenchymal #StemCell #Gene Expression

Influence of dietary #inosine and #vitaminC supplementation on growth, #blood #chemistry, oxidative stress, innate and adaptive #immune responses of #redseabream,#Pagrusmajorjuvenile

Diverse effects of the common #hippopotamus on plant communities and soil #chemistry

Conducting# Polymer Coating on High-voltage #Cathode Based on Soft #Chemistry Approach Towards Improving Battery Performance

The #Chemistry of #Europium (III) Encountering #DNA: Sprouting Unique Sequence-Dependent Performances for Multifunctional Time-Resolved Luminescent Assays

#Coagulation performance of# cucurbit[8]uril for the removal of #azodyes: effect of solution #chemistry and #coagulant dose

Interactive effects of dissolved #nitrogen, #phosphorus and litter #chemistry on stream #fungal decomposers

The #Chemistry and #Pharmacology of Synthetic #Cannabinoid #Receptor #Agonist New #Psychoactive Substances: #Evolution

#Benzisoxazole: a privileged #scaffold for #medicinalchemistry

Friday, 17 August 2018

Species-specific plant-soil feedbacks alter herbivore-induced #gene expression and defense #chemistry in #Plantagolanceolata

#Lipases in #GreenChemistry: Deep #EutecticSolvents (DES) as New #GreenSolvents

Putting #chemistry back in #biology

Recent advances in the #medicinalchemistry of group II and group III mGlu receptors

Novel 1,2,3-triazolium-based dicationic #amphiphiles synthesized using #click-chemistry approach for efficient plasmid delivery

Advances in indoleamine 2,3-dioxygenase 1 #medicinalchemistry

Applications of #ClickChemistry in the Development of HIV #Protease #Inhibitors

#Autocatalytic Synthesis of# Bifluoride Ionic Liquids via SuFEx Click #Chemistry

N-(Sulfamoylbenzoyl)-L-proline Derivatives as Potential #Non-β-lactam ESBL Inhibitors: Structure-Based #Lead Identification, #MedicinalChemistry and #Synergistic #Antibacterial Activities

H2 reduction of Gd- and Sm-doped ceria compared to pure CeO2 at high temperatures: effect on structure, #oxygen# nonstoichiometry, #hydrogen solubility and #hydroxyl #chemistry

#Fullerenols Revisit: Highly Monodispersed #Photoluminescent #Nanomaterials and Ideal Building Blocks for #SupramolecularChemistry

Coordination #Chemistry and #QTAIMAnalysis of# Homoleptic Dithiocarbamate Complexes, M(S2CNiPr2)4 (M = Ti, Zr, Hf, Th, U, Np)

Click #Chemistry-Assisted Synthesis of a #β-d-Galactose-Targeted SiO2@RC Shell-Core Structure as a #Nanoplatform for #Metal-Based Complex Delivery

NHC #Ligated #Group11 #Metal-Arylthiolates Containing an #Azide Functionality Amenable to "Click" Reaction #Chemistry

The last #universal common #ancestor between #ancient #Earth #chemistry and the onset of #genetics

Tuesday, 14 August 2018

#Asymmetric #Cationic #Phosphines: Synthesis, Coordination #Chemistry, and Reactivity

Click #chemistry in #sphingolipid #research

#Computer vision-based analytical chemistry applied to determining iron in commercial pharmaceutical formulations

#Cobaltoxide materials for the #oxygen evolution #catalysis via single-source #precursor #chemistry

#Ectomycorrhizal #fungal species differentially affect the induced defensive #chemistry of lodgepole pine

Click #Chemistry-Based #DNA Labeling of Cells for #Barcoding Applications

Low-Pressure Flow #Chemistry of CuAAC Click Reaction #Catalyzed by #Nanoporous AuCu Membrane

A comprehensive overview of directing groups applied in #metal-catalysed C-H functionalisation #chemistry

Functionalised# tetrathiafulvalene- (TTF-) macrocycles: recent trends in applied #supramolecularchemistry

Profiling and Application of #Photoredox C(sp3)-C(sp2) #Cross-Coupling in #MedicinalChemistry

A novel approach to study the #morphology and #chemistry of #pollen in a# phylogenetic context, applied to the #halophytic taxon# Nitraria L.(Nitrariaceae)

#Chemistry, information and Frank: a tribute to #FrankBrown

Aphid #infestation leads to plant part-specific changes in #phloemsap #chemistry, which may indicate niche construction

Friday, 10 August 2018

Facile Gene Delivery Derived from Branched Low Molecular Weight #Polyethylenimine by High Efficient #Chemistry

@chemistrysummit Impact of the precursor #chemistry and process conditions on the cell-to-cell variability in 1T-1R based HfO2 RRAM devices

@chemistrysummit

Impact of the precursor #chemistry and process conditions on the cell-to-cell variability in 1T-1R based HfO2 RRAM devices

Effect of pomegranate peel extract on shelf life of strawberries: #computationalchemistry approaches to assess #antifungal mechanisms involved

Discovery of Novel #Molecules for Corrosion Protection Using #ComputationalChemistry

#Molecularchemistry approaches for tuning the properties of two-dimensional transition #metaldichalcogenides

Elucidating the Influences of Size, #SurfaceChemistry, and Dynamic Flow on #Cellular Association of #Nanoparticles Made by #Polymerization-Induced Self-Assembly

Modulation of #Hydrophobic Interaction by Mediating Surface #Nanoscale Structure and #Chemistry, not Monotonically by #Hydrophobicity

Influence of dendrimer #surfacechemistry and pH on the binding and release pattern of chalcone studied by molecular #dynamics simulations

Targeted #Ligand-Exchange #Chemistry on #CesiumLeadHalide Perovskite Quantum Dots for High-Efficiency #Photovoltaics

The global impact of the International Federation of #ClinicalChemistry and #Laboratory #Medicine, Education and Management Division: engaging #stakeholders and assessing HbA1c quality in a multicentre study across #China

The global impact of the International Federation of #ClinicalChemistry and #Laboratory #Medicine, Education and Management Division: engaging #stakeholders and assessing HbA1c quality in a multicentre study across #China

Dynamic modulation of external conditions can transform #chemistry into logic gates.

Quantification of intramolecular click #chemistry modified #syntheticpeptide #isomers in mixtures using tandem #massspectrometry and the survival yield technique

Thursday, 9 August 2018

Slowing the #Kinetics of #AluminaSol-Gel #Chemistry for Controlled #Catalyst Overcoating and Improved #Catalyst Stability and Selectivity.

Tackling Grand Challenges of the# 21stCentury with #ElectroanalyticalChemistry

#Nanoscale self-assembly of thermoelectric materials: A review of #chemistry-based approaches

#N-Heterocyclic Carbene-#Catalyzed α,β-Unsaturated #Aldehydes Umpolung in Fullerene #Chemistry: Construction of [60]Fullerene-Fused Cyclopentan-1-ones and Cyclohex-2-en-1-ones

#Chemistry for #PositronEmission #Tomography: Recent Advances in 11C-, 18F-, 13N- and 15O-labeling Reactions

The #anticonvulsant and #anti-plasmid #conjugation potential of #Thymusvulgaris #chemistry: An #invivo murine and #invitro study

Recent Progress of Imprinted #Nanomaterials in #AnalyticalChemistry

#TissueRegeneration without #StemCellTransplantation: Self-Healing Potential from Ancestral #Chemistry and# Physical Energies.

Tuning the spin-related transport properties of FePc on Au(111) through single-molecule #chemistry.

#Halogenation #Chemistry of #Hydraulic Fracturing #Additives under Highly Saline Simulated Subsurface Conditions.

#Mimicking the #chemistry of #natural #eumelanin synthesis: the KE sequence in #polypeptides and in #proteins allows for a specific control of nanosized functional #polydopamine formation.

Tuesday, 7 August 2018

Employing Photoredox #Catalysis for #DNA-Encoded #Chemistry: Decarboxylative #Alkylation of a-#AminoAcids.

Current #Opioid Overdose Crisis: Some Comments on the #Chemicobiological Aspects of Tolerance/Dependence and Abuse Based on #ComputationalChemistry and #Biology.

Zigzag #Ligands for Transversal Design in #ReticularChemistry: Unveiling New Structural Opportunities for #MetalOrganic Frameworks.

#Iron-#catalysedchemistry in the #gastrointestinaltract: Mechanisms, #kinetics and consequences

Seeing the Light: Advancing #MaterialsChemistry through #Photopolymerization.

Gas-Generating #Nanoplatforms: #MaterialChemistry, #Multifunctionality, and Gas Therapy.

Evaluation of point-of-care analysers for #blood gas and #clinicalchemistry in #Hermann'stortoises (Testudo hermanni).

Effects of Surface #Nanotopography and #Calcium #Chemistry of #Titanium #BoneImplants on Early #BloodPlatelet and #Macrophage #CellFunction.

Chemistry of 4-[(4-bromophenyl)ethynyl]#pyridine at #metal surfaces studied by #STM.

Advances in the #chemistry and #pharmacological potential of #coumarinolignans.

#Chemistry-driven #Epigenetic Investigation of #Histone and #DNA Modifications.

#Chemistry-driven #Epigenetic Investigation of #Histone and #DNAModifications

Reference intervals of routine #clinicalchemistry parameters among apparently healthy young adults in Amhara National Regional State, #Ethiopia.

Effectiveness and limitations of #computationalchemistry and #massspectrometry in the rational design of target-specific shift reagents for ion mobility #spectrometry.

Merging #HeterocyclicChemistry and #Biocatalysis in One-Pot Processes through #Compartmentalization of the Reaction Steps.

#Photoinduced Plasmon-Driven #Chemistry in trans-1,2-bis(4-pyridyl)ethylene Gold #NanosphereOligomers

#Chemometrics in #analyticalchemistry-part II: modeling, validation, and applications.

Intrinsically Tuning the #Electromechanical Properties of #Elastomeric #Dielectrics: A #Chemistry Perspective.

Review of #NaturalProduct #Biosynthesis: #Chemical Logic and #Enzymatic Machinery #NaturalProduct #Biosynthesis: #Chemical Logic and #Enzymatic Machinery

#Chemistry meets #epigenetics: from #chromatin tools to small molecules affecting the readout of our #genomes

Monday, 11 June 2018

#LegoChemistry-Inspired Synthesis of Extra-large Pore# Zeolite ECNU-9 with Intersecting 14*12-Ring Channels

Solution and Solid State #StructuralChemistry of Th(IV) and U(IV) 4-#Hydroxybenzoates

The #MedicinalChemistry and Use of #Myosin II #Inhibitor ( S)-#Blebbistatin and Its Derivatives

Growth, carcass traits, cecal microbial counts, and #bloodchemistry of #meat-type quail fed #diets supplemented with #humicacid and #blackcuminseeds

#NovelPeptide Ion #Chemistry Associated with Gold (I) #Cationization: Preferential Cleavage at #Lysine Residues

From underlying #chemistry to #therapeutic potential: open questions in the new field of #lysine #polyphosphorylation

#CarbonChemistry in IRC+10216: #Infrared Detection of #Diacetylene

Deactivation of excited states in transition #metalcomplexes: Insight from #computationalchemistry

Evaluation of BD Vacutainer® Barricor™ #blood collection tubes for routine #chemistry testing on a #RocheCobas® 8000 Platform

Application of #bioconjugation #chemistry on #biosensor fabrication for detection of #TAR-DNA binding #protein 43

Monday, 4 June 2018

A matrix-assisted laser desorption/ionization mass spectroscopy method for the analysis of small molecules by integrating chemical labeling with the supramolecular chemistry of cucurbituril

Abstract

Although several methods have realized the analysis of low molecular weight (LMW) compounds using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) by overcoming the problem of interference with MS signals in the low mass region derived from conventional organic matrices, this emerging field still requires strategies to address the issue of analyzing complex samples containing LMW components in addition to the LMW compounds of interest, and solve the problem of lack of universality.

The recent progress of isoxazole in medicinal chemistry

Abstract

Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Developing compounds with heterocycle rings has been one of the trends. The integration of isoxazole ring can offer improved physical-chemical properties. Because of the unique profiles, isoxazole ring becomes a popular moiety in compounds design

A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models

Abstract

Photodynamic therapy (PDT) represents a non-toxic and non-mutagenic antitumor therapy. The photosensitizer's (PS) chemo-physical properties are essential for the therapy, being responsible for the biological effects induced in the targeted tissues. In this study, we present the synthesis and development of some glycoconjugated porphyrins based on lectin-type receptor interaction. They were tested in vitro for finally choosing the most effective chemical structure for an optimum antitumor outcome.

Defect Chemistry of Oxides for Energy Applications

Abstract

Oxides are widely used for energy applications, as solid electrolytes in various solid oxide fuel cell devices or as catalysts (often associated with noble metal particles) for numerous reactions involving oxidation or reduction. Defects are the major factors governing the efficiency of a given oxide for the above applications. In this paper, the common defects in oxide systems and external factors influencing the defect concentration and distribution are presented, with special emphasis on ceria (CeO2 ) based materials.

Click Chemistry-based Discovery of [3-Hydroxy-5-(1H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia.

Abstract

As a gene associated with anemia, the #erythropoiesis gene is physiologically expressed under hypoxia regulated by hypoxia-inducing factor-α (HIF-α). Thus, stabilizing HIF-α is a potent strategy to stimulate the expression and secretion of erythropoiesis. In this study we applied click #chemistry to the discovery of HIF prolyl hydroxylase 2 (HIF-PHD2) inhibitors for the first time and a series of triazole compounds showed preferable inhibitory activity in #fluorescence #polarization assay.

Exploiting Synergistic Effects in Organozinc Chemistry for Direct Stereoselective C-Glycosylation Reactions at Room Temperature

Abstract

Pairing a range of bis(aryl) zinc reagents ZnAr2 with the stronger Lewis acidic [(ZnArF2)] (ArF = C6F5), enables highly stereoselective cross-coupling between glycosyl bromides and ZnAr2 without the use of a transition metal. Reactions occur at room temperature with excellent levels of stereoselectivity, where ZnArF2 acts as a non-coupling partner although its presence is crucial for the execution of the C(sp2)-C(sp3) bond formation process.

Biological chemistry without borders

Recent Developments in Carbonylation Chemistry Using [13 C]CO, [11 C]CO and [14 C]CO

Abstract

Carbon monoxide represents the most important C1-building block for the chemical industry, both for the production of bulk and fine chemicals, but also for synthetic fuels. Yet, its toxicity and subsequently its cautious handling has limited its applications in medicinal chemistry research and in particular for the synthesis of pharmaceutically relevant molecules. Recent years have nevertheless witnessed a considerable headway on the development of carbon monoxide surrogates and reactor systems

A Recent History of HNO (Nitroxyl) Chemistry, Pharmacology and Therapeutic Potential.

Abstract

Due to the excitement surrounding the discovery of nitric oxide (NO) as an endogenously generated signaling molecule, numerous other nitrogen oxides were also investigated as possible physiological mediators. Among these was nitroxyl (HNO). Over the past 25 years or so, a significant amount of work by this lab and many others has discovered that

Theoretical Exploration of the Role of CO2 in an Imidazolium Cation-Based Ionic Liquid | SciTechnol

Theoretical Exploration of the Role of CO2 in an Imidazolium Cation-Based Ionic Liquid | SciTechnol: Optimized structures of imidazolium cation-based ionic liquids (ILs) and CO2 were obtained using the Gaussian 09 software package and density functional theory (B3LYP/6-3..

Sunday, 3 June 2018

The Simms Constants as Parameters in Hyperbolic Functions Related to Acid-Base Titration Curves | SciTechnol

The Simms Constants as Parameters in Hyperbolic Functions Related to Acid-Base Titration Curves | SciTechnol: The Simms constants (gi) are parameters of transformed equations for acid-base titration curves, obtained from rational functions of the Padé type. The relationshi..

Saturday, 2 June 2018

Impact of crop residue management on crop production and soil chemistry after seven years of crop rotation in temperate climate, loamy soils.

Abstract

Society is increasingly demanding a more sustainable management of agro-ecosystems in a context of climate change and an ever growing global population. The fate of crop residues is one of the important management aspects under debate, since it represents an unneglectable quantity of organic matter which can be kept in or removed from the agro-ecosystem. The topic of residue management is not new, but the need for global conclusion on the impact of crop residue management on the agro-ecosystem linked to local pedo-climatic conditions has become apparent with an increasing amount of studies showing a diversity of conclusions.

Radical Rearrangement #Chemistry in #Ultraviolet #Photodissociation of #Iodotyrosine Systems: Insights from Metastable Dissociation,#Infrared Ion# Spectroscopy, and Reaction Pathway Calculations

Abstract

We report on the ultraviolet photodissociation (UVPD) chemistry of protonated tyrosine, iodotyrosine, and diiodotyrosine. Distonic loss of the iodine creates a high-energy radical at the aromatic ring that engages in hydrogen/proton rearrangement chemistry. Based on UVPD kinetics measurements, the appearance of this radical is coincident with the UV irradiation pulse (8 ns). Conversely, sequential UVPD product ions exhibit metastable decay on ca. 100 ns timescales.

Elucidating the role of surface chemistry on cationic phosphorus dendrimer-siRNA complexation

Abstract

In the field of dendrimers targeting small interfering RNA (siRNA) delivery, dendrimer structural properties, such as the flexibility/rigidity ratio, play a crucial role in the efficiency of complexation. However, advances in organic chemistry have enabled the development of dendrimers that differ only by a single atom on their surface terminals. This is the case for cationic phosphorus dendrimers functionalized with either pyrrolidinium (DP) or morpholinium (DM) terminal groups.

Friday, 1 June 2018

Achieving biopolymer synergy in systems chemistry

Abstract

Synthetic and materials chemistry initiatives have enabled the translation of the macromolecular functions of biology into synthetic frameworks. These explorations into alternative chemistries of life attempt to capture the versatile functionality and adaptability of biopolymers in new orthogonal scaffolds. Information storage and transfer, however, so beautifully represented in the central dogma of biology, require multiple components functioning synergistically. Over a single decade, the emerging field of systems chemistry has begun to catalyze the construction of mutualistic biopolymer networks, and t

Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in rats.

Abstract

PEGylated polylysine dendrimers have demonstrated potential as inhalable drug delivery systems that can improve the treatment of lung cancers. Their treatment potential may be enhanced by developing constructs that display prolonged lung retention, together with good systemic absorption, the capacity to passively target lung tumours from the blood and highly selective, yet rapid liberation in the tumour microenvironment. This study sought to characterise how the nature of cathepsin B cleavable peptide linkers, used to conjugate doxorubicin to a PEGylated (PEG570) G4 polylysine dendrimer, affect drug liberation kinetics and intravenous and pulmonary pharmacokinetics in rats. The construct bearing a self-emolative diglycolic acid-V-Citrulline linker exhibited faster doxorubicin release kinetics compared to constructs bearing self emolative diglycolic acid-GLFG, or non-self emolative glutaric acid-GLFG linkers. The V-Citrulline construct exhibited slower plasma clearance, but faster absorption from the lungs than a GLFG construct, although mucociliary clearance and urinary elimination were unchanged. Doxorubicin-conjugation enhanced localisation in the bronchoalveolar lavage fluid compared to lung tissue, suggesting that projection of doxorubicin from the dendrimer surface reduced tissue uptake. These data show that the linker chemistry employed to conjugate drugs to PEGylated carriers can affect drug release profiles and systemic and lung disposition.

KEYWORDS:

cathepsin B; dendrimer; doxorubicin; lung clearance; pharmacokinetics; pulmonary

Quality Control Practices for Chemistry and Immunochemistry in a Cohort of 21 Large Academic Medical Centers.

Abstract

OBJECTIVES:

In the United States, minimum standards for quality control (QC) are specified in federal law under the Clinical Laboratory Improvement Amendment and its revisions. Beyond meeting this required standard, laboratories have flexibility to determine their overall QC program.

METHODS:

We surveyed chemistry and immunochemistry QC procedures at 21 clinical laboratories within leading academic medical centers to assess if standardized QC practices exist for chemistry and immunochemistry testing.

RESULTS:

We observed significant variation and unexpected similarities in practice across laboratories, including QC frequency, cutoffs, number of levels analyzed, and other features.

CONCLUSIONS:

This variation in practice indicates an opportunity exists to establish an evidence-based approach to QC that can be generalized across institutions.

Wednesday, 30 May 2018

Carbenes and Nitrenes: Recent Developments in Fundamental Chemistry.

2018 May 29. doi: 10.1002/anie.201804863. [Epub ahead of print]

Carbenes and Nitrenes: Recent Developments in Fundamental Chemistry.

Wentrup C1.

Author information

Abstract

There has been significant progress in the direct observation of carbenes, nitrenes, and many other reactive intermediates in recent years due to the application of matrix photolysis and flash vacuum pyrolysis linked with matrix isolation at cryogenic temperatures. Our understanding of singlet and triplet states has improved through the interplay of spectroscopy and computations. Bistable carbenes and nitrenes as well as many examples of tunneling have been discovered. Numerous rearrangements and fragmentations have been documented. This minireview aims to give an overview of some of these developments but will not generally cover laser flash photolysis and chemical reactions in liquid solution.

QUICK LINKS

Wednesday, 5 September 2018

Rapid assessment of #As and other #elements in naturally-contaminated #calcareous soil through #hyperspectral #VISNIR analysis

Hyperbranched mixed-mode #anion-exchange #polymeric #sorbent for highly selective extraction of nine #acidic #nonsteroidal #antiinflammatory drugs from human #urine

A sensitive #fluorometric #DNA #nanobiosensor based on a new #fluorophore for #tumor suppressor #gene detection

Innovative unattended #SEM-EDS #analysis for #asbestos #fiber quantification

Ultrasensitive sensing of #Androctonusaustralis hector #scorpion #venom toxins in biological fluids using an #electrochemical #graphene quantum dots/#nanobody-based platform

Determination of #Se8 in sediments by #gaschromatography-#massspectrometry

Sunday, 2 September 2018

Saturday, 1 September 2018

Tuesday, 28 August 2018

Saturday, 25 August 2018

Wednesday, 22 August 2018

Monday, 20 August 2018

Friday, 17 August 2018